Cargando…
IDH1(R132H) in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis
BACKGROUND: The high frequency of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in diffuse gliomas indicates its importance in the process of gliomagenesis. These mutations result in loss of the normal function and acquisition of the neomorphic activity converting α-ketoglutarate to 2-hydr...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856348/ https://www.ncbi.nlm.nih.gov/pubmed/27145078 http://dx.doi.org/10.1371/journal.pone.0154726 |