Inactive mutants of human pyridoxine 5′‐phosphate oxidase: a possible role for a noncatalytic pyridoxal 5′‐phosphate tight binding site

Pyridoxal 5′‐phosphate (PLP) is a cofactor for many vitamin B6‐requiring enzymes that are important for the synthesis of neurotransmitters. Pyridoxine 5′‐phosphate oxidase (PNPO) is one of two enzymes that produce PLP. Some 16 known mutations in human PNPO (hPNPO), including R95C and R229W, lead to...

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Detalles Bibliográficos
Autores principales: Ghatge, Mohini S., Karve, Sayali S., David, Tanya M. S., Ahmed, Mostafa H., Musayev, Faik N., Cunningham, Kendra, Schirch, Verne, Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856418/
https://www.ncbi.nlm.nih.gov/pubmed/27419045
http://dx.doi.org/10.1002/2211-5463.12042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856418/
https://www.ncbi.nlm.nih.gov/pubmed/27419045
http://dx.doi.org/10.1002/2211-5463.12042

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