Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

Ubiquitination is a central process affecting all facets of cellular signaling and function(1). A critical step in ubiquitination is the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate or a growing ubiquitin chain, which is mediated by E3 ubiquitin ligases. RING-type E3...

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Detalles Bibliográficos
Autores principales: Lechtenberg, Bernhard C., Rajput, Akhil, Sanishvili, Ruslan, Dobaczewska, Małgorzata K., Ware, Carl F., Mace, Peter D., Riedl, Stefan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856479/
https://www.ncbi.nlm.nih.gov/pubmed/26789245
http://dx.doi.org/10.1038/nature16511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856479/
https://www.ncbi.nlm.nih.gov/pubmed/26789245
http://dx.doi.org/10.1038/nature16511

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