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Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
Ubiquitination is a central process affecting all facets of cellular signaling and function(1). A critical step in ubiquitination is the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate or a growing ubiquitin chain, which is mediated by E3 ubiquitin ligases. RING-type E3...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856479/ https://www.ncbi.nlm.nih.gov/pubmed/26789245 http://dx.doi.org/10.1038/nature16511 |