A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy

Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking both DNA replication and repair by inhibiting the bifunction...

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Detalles Bibliográficos
Autores principales: Liu, Wenpeng, Zhou, Mian, Li, Zhengke, Li, Hongzhi, Polaczek, Piotr, Dai, Huifang, Wu, Qiong, Liu, Changwei, Karanja, Kenneth K., Popuri, Vencat, Shan, Shu-ou, Schlacher, Katharina, Zheng, Li, Campbell, Judith L., Shen, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856754/
https://www.ncbi.nlm.nih.gov/pubmed/27211550
http://dx.doi.org/10.1016/j.ebiom.2016.02.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856754/
https://www.ncbi.nlm.nih.gov/pubmed/27211550
http://dx.doi.org/10.1016/j.ebiom.2016.02.043

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