Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents

Taking 12-N-p-chlorobenzyl sophoridinol 2 as a lead, a series of novel sophoridinic derivatives with various 3′-substituents at the 11–side chain were synthesized and evaluated for their anticancer activity from sophoridine (1), a natural antitumor medicine. Among them, the sophoridinic ketones 5a–b...

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Detalles Bibliográficos
Autores principales: Bi, Chongwen, Ye, Cheng, Li, Yinghong, Zhao, Wuli, Shao, Rongguang, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856954/
https://www.ncbi.nlm.nih.gov/pubmed/27175333
http://dx.doi.org/10.1016/j.apsb.2016.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856954/
https://www.ncbi.nlm.nih.gov/pubmed/27175333
http://dx.doi.org/10.1016/j.apsb.2016.03.004

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