Cargando…
Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability
Maintenance of proper chromatin states and genomic stability is vital for normal development and health across a range of organisms. Here, we report on the role of KLLN in maintenance of pericentric H3K9 trimethylation (H3K9me3) and genomic stability. Germline hypermethylation of KLLN, a gene uncove...
Autores principales: | Nizialek, Emily A., Sankunny, Madhav, Niazi, Farshad, Eng, Charis |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856962/ https://www.ncbi.nlm.nih.gov/pubmed/26673699 http://dx.doi.org/10.1093/nar/gkv1481 |
Ejemplares similares
-
Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells
por: Sankunny, Madhav, et al.
Publicado: (2020) -
A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells
por: Eymery, Angéline, et al.
Publicado: (2009) -
KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells
por: Sankunny, Madhav, et al.
Publicado: (2018) -
Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast
por: Suzuki, Shota, et al.
Publicado: (2016) -
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
por: Sarkies, Peter, et al.
Publicado: (2012)