The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons

We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA turnover, the total mRNA concentration remained approximately constant. Some gen...

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Detalles Bibliográficos
Autores principales: García-Martínez, José, Delgado-Ramos, Lidia, Ayala, Guillermo, Pelechano, Vicent, Medina, Daniel A., Carrasco, Fany, González, Ramón, Andrés-León, Eduardo, Steinmetz, Lars, Warringer, Jonas, Chávez, Sebastián, Pérez-Ortín, José E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856968/
https://www.ncbi.nlm.nih.gov/pubmed/26717982
http://dx.doi.org/10.1093/nar/gkv1512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856968/
https://www.ncbi.nlm.nih.gov/pubmed/26717982
http://dx.doi.org/10.1093/nar/gkv1512

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