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Robust detection of alternative splicing in a population of single cells

Single cell RNA-seq experiments provide valuable insight into cellular heterogeneity but suffer from low coverage, 3′ bias and technical noise. These unique properties of single cell RNA-seq data make study of alternative splicing difficult, and thus most single cell studies have restricted analysis...

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Detalles Bibliográficos
Autores principales: Welch, Joshua D., Hu, Yin, Prins, Jan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856971/
https://www.ncbi.nlm.nih.gov/pubmed/26740580
http://dx.doi.org/10.1093/nar/gkv1525