An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation

Active DNA demethylation (ADDM) in mammals occurs via hydroxylation of 5-methylcytosine (5mC) by TET and/or deamination by AID/APOBEC family enzymes. The resulting 5mC derivatives are removed through the base excision repair (BER) pathway. At present, it is unclear how the cell manages to eliminate...

Descripción completa

Detalles Bibliográficos
Autores principales: Grin, Inga, Ishchenko, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856981/
https://www.ncbi.nlm.nih.gov/pubmed/26843430
http://dx.doi.org/10.1093/nar/gkw059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856981/
https://www.ncbi.nlm.nih.gov/pubmed/26843430
http://dx.doi.org/10.1093/nar/gkw059

Ejemplares similares