The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

The tumor-suppressive let-7 microRNA family targets various oncogene-encoding mRNAs. We identify the let-7 targets HMGA2, LIN28B and IGF2BP1 to form a let-7 antagonizing self-promoting oncogenic triangle. Surprisingly, 3′-end processing of IGF2BP1 mRNAs is unaltered in aggressive cancers and tumor-d...

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Detalles Bibliográficos
Autores principales: Busch, Bianca, Bley, Nadine, Müller, Simon, Glaß, Markus, Misiak, Danny, Lederer, Marcell, Vetter, Martina, Strauß, Hans-Georg, Thomssen, Christoph, Hüttelmaier, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856984/
https://www.ncbi.nlm.nih.gov/pubmed/26917013
http://dx.doi.org/10.1093/nar/gkw099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856984/
https://www.ncbi.nlm.nih.gov/pubmed/26917013
http://dx.doi.org/10.1093/nar/gkw099

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