Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains

Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies determined experimentally. Here, instead, we develop a fitting-free, minimal model: bivalent or multivalent red and green...

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Detalles Bibliográficos
Autores principales: Brackley, Chris A., Johnson, James, Kelly, Steven, Cook, Peter R., Marenduzzo, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856988/
https://www.ncbi.nlm.nih.gov/pubmed/27060145
http://dx.doi.org/10.1093/nar/gkw135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856988/
https://www.ncbi.nlm.nih.gov/pubmed/27060145
http://dx.doi.org/10.1093/nar/gkw135

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