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Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains
Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies determined experimentally. Here, instead, we develop a fitting-free, minimal model: bivalent or multivalent red and green...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856988/ https://www.ncbi.nlm.nih.gov/pubmed/27060145 http://dx.doi.org/10.1093/nar/gkw135 |