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Resolving individual steps of Okazaki fragment maturation at msec time-scale
DNA polymerase delta (Pol δ) is responsible for elongation and maturation of Okazaki fragments. Pol δ and flap-endonuclease FEN1, coordinated by the PCNA clamp, remove RNA primers and produce ligatable nicks. We have studied this process with the Saccharomyces cerevisiae machinery at msec resolution...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857878/ https://www.ncbi.nlm.nih.gov/pubmed/27065195 http://dx.doi.org/10.1038/nsmb.3207 |