Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice and humans. An in-frame insertion polymorphism in the murine Ltbp4 gene associates with partial protection against muscular dystrophy....

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Detalles Bibliográficos
Autores principales: Lamar, Kay-Marie, Bogdanovich, Sasha, Gardner, Brandon B., Gao, Quan Q., Miller, Tamari, Earley, Judy U., Hadhazy, Michele, Vo, Andy H., Wren, Lisa, Molkentin, Jeffery D., McNally, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858180/
https://www.ncbi.nlm.nih.gov/pubmed/27148972
http://dx.doi.org/10.1371/journal.pgen.1006019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858180/
https://www.ncbi.nlm.nih.gov/pubmed/27148972
http://dx.doi.org/10.1371/journal.pgen.1006019

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