Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins from satellites and their relocation to centrio...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Lee, Kwanwoo, Malonis, Ryan, Sanchez, Irma, Dynlacht, Brian D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858382/
https://www.ncbi.nlm.nih.gov/pubmed/27146717
http://dx.doi.org/10.7554/eLife.12950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858382/
https://www.ncbi.nlm.nih.gov/pubmed/27146717
http://dx.doi.org/10.7554/eLife.12950

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