Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

BACKGROUND: Hepatotoxicity accounts for a substantial number of drugs being withdrawn from the market. Using traditional animal models to detect hepatotoxicity is expensive and time-consuming. Alternative in vitro methods, in particular cell-based high-throughput screening (HTS) studies, have provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Marlene Thai, Huang, Ruili, Sedykh, Alexander, Wang, Wenyi, Xia, Menghang, Zhu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858396/
https://www.ncbi.nlm.nih.gov/pubmed/26383846
http://dx.doi.org/10.1289/ehp.1509763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858396/
https://www.ncbi.nlm.nih.gov/pubmed/26383846
http://dx.doi.org/10.1289/ehp.1509763

Ejemplares similares