HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but indepe...

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Detalles Bibliográficos
Autores principales: Gibbs-Seymour, Ian, Fontana, Pietro, Rack, Johannes Gregor Matthias, Ahel, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858568/
https://www.ncbi.nlm.nih.gov/pubmed/27067600
http://dx.doi.org/10.1016/j.molcel.2016.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858568/
https://www.ncbi.nlm.nih.gov/pubmed/27067600
http://dx.doi.org/10.1016/j.molcel.2016.03.008

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