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eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy

Photodynamic therapy (PDT) with protoporphyrin IX (PpIX), which is endogenously derived from 5-aminolevulinic acid (5-ALA) or its derivatives, is a promising modality for the treatment of both pre-malignant and malignant lesions. However, the mechanisms of how ALA-induced PpIX selectively accumulate...

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Detalles Bibliográficos
Autores principales: Fan, Zhichao, Cui, Xiaojun, Wei, Dan, Liu, Wei, Li, Buhong, He, Hao, Ye, Huamao, Zhu, Naishuo, Wei, Xunbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858656/
https://www.ncbi.nlm.nih.gov/pubmed/27150264
http://dx.doi.org/10.1038/srep25353