Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA

Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known co...

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Detalles Bibliográficos
Autores principales: Álvarez, Vanesa, Viñas, Laura, Gallego-Sánchez, Alfonso, Andrés, Sonia, Sacristán, María P., Bueno, Avelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858703/
https://www.ncbi.nlm.nih.gov/pubmed/27151298
http://dx.doi.org/10.1038/srep25513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858703/
https://www.ncbi.nlm.nih.gov/pubmed/27151298
http://dx.doi.org/10.1038/srep25513

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