3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling

Excessive UV radiation and reactive oxygen species (ROS) cause retinal pigment epithelium (RPE) cell injuries. Nrf2 regulates transcriptional activation of many anti-oxidant genes. Here, we tested the potential role of 3H-1,2-dithiole-3-thione (D3T) against UV or ROS damages in cultured RPE cells (b...

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Detalles Bibliográficos
Autores principales: Li, Ke-ran, Yang, Su-qing, Gong, Yi-qing, Yang, Hong, Li, Xiu-miao, Zhao, Yu-xia, Yao, Jin, Jiang, Qin, Cao, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858705/
https://www.ncbi.nlm.nih.gov/pubmed/27151674
http://dx.doi.org/10.1038/srep25525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858705/
https://www.ncbi.nlm.nih.gov/pubmed/27151674
http://dx.doi.org/10.1038/srep25525

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