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Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the f...

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Detalles Bibliográficos
Autores principales: Rathan, Swetha, Ankeny, Casey J., Arjunon, Sivakkumar, Ferdous, Zannatul, Kumar, Sandeep, Fernandez Esmerats, Joan, Heath, Jack M., Nerem, Robert M., Yoganathan, Ajit P., Jo, Hanjoong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858741/
https://www.ncbi.nlm.nih.gov/pubmed/27151744
http://dx.doi.org/10.1038/srep25397