The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB(2), TRPV1, TRPA1 and yet unidentified receptor targets

BACKGROUND: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action of cannabinoids and they not only express cannabinoid receptors type I and II (C...

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Detalles Bibliográficos
Autores principales: Lowin, Torsten, Pongratz, Georg, Straub, Rainer H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858820/
https://www.ncbi.nlm.nih.gov/pubmed/27158245
http://dx.doi.org/10.1186/s12950-016-0114-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858820/
https://www.ncbi.nlm.nih.gov/pubmed/27158245
http://dx.doi.org/10.1186/s12950-016-0114-7

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