Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its impact on heterodimer DNA binding specificity...

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Detalles Bibliográficos
Autores principales: Isakova, Alina, Berset, Yves, Hatzimanikatis, Vassily, Deplancke, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Gene Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858977/
https://www.ncbi.nlm.nih.gov/pubmed/26912662
http://dx.doi.org/10.1074/jbc.M115.691154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858977/
https://www.ncbi.nlm.nih.gov/pubmed/26912662
http://dx.doi.org/10.1074/jbc.M115.691154

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