Cargando…

Parkin Regulates the Activity of Pyruvate Kinase M2

Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Kun, Li, Fanzhou, Han, Haichao, Chen, Yue, Mao, Zebin, Luo, Jianyuan, Zhao, Yingming, Zheng, Bin, Gu, Wei, Zhao, Wenhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858978/ https://www.ncbi.nlm.nih.gov/pubmed/26975375 http://dx.doi.org/10.1074/jbc.M115.703066

Ejemplares similares

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
por: Bassi, Rekha, et al.
Publicado: (2017)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
por: Moore, Samantha F., et al.
Publicado: (2011)

Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
por: Hayes, Sebastian D., et al.
Publicado: (2012)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection
por: Gold, Matthew G., et al.
Publicado: (2013)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes
por: Tan, Shi-Xiong, et al.
Publicado: (2012)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
por: Pakharukova, Natalia, et al.
Publicado: (2021)

MAPKKK-independent Regulation of the Hog1 Stress-activated Protein Kinase in Candida albicans
por: Cheetham, Jill, et al.
Publicado: (2011)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
por: Leiss, Veronika, et al.
Publicado: (2011)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells
por: Dominguez, Veronica, et al.
Publicado: (2011)

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
por: James, Richard G., et al.
Publicado: (2013)

Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin
por: Mishra, Jayshree, et al.
Publicado: (2017)

A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation
por: Elsner, Daniel J., et al.
Publicado: (2019)

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets
por: Moore, Samantha F., et al.
Publicado: (2013)

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module
por: Glatz, Gábor, et al.
Publicado: (2013)

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2
por: Suvasini, Ramaswamy, et al.
Publicado: (2011)

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase
por: Bamberger, Martina, et al.
Publicado: (2011)

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
por: Rondas, Dieter, et al.
Publicado: (2011)

PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110α to the Golgi Apparatus
por: Wang, Xiao, et al.
Publicado: (2013)

Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation
por: Kankipati, Harish Nag, et al.
Publicado: (2015)

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
por: Kokoszka, Malgorzata E., et al.
Publicado: (2018)

Selective inhibition of intestinal guanosine 3′,5′-cyclic monophosphate signaling by small-molecule protein kinase inhibitors
por: Bijvelds, Marcel J. C., et al.
Publicado: (2018)

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
por: Xie, Zhonglin, et al.
Publicado: (2008)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Lobe-specific Functions of Ca(2+)·Calmodulin in αCa(2+)·Calmodulin-dependent Protein Kinase II Activation
por: Jama, Abdirahman M., et al.
Publicado: (2011)

Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5
por: Bernatík, Ondřej, et al.
Publicado: (2014)

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity
por: Burmeister, Brian T., et al.
Publicado: (2015)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Pulsatile Hormonal Signaling to Extracellular Signal-regulated Kinase: EXPLORING SYSTEM SENSITIVITY TO GONADOTROPIN-RELEASING HORMONE PULSE FREQUENCY AND WIDTH
por: Perrett, Rebecca M., et al.
Publicado: (2014)

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in β Cells
por: Wuttke, Anne, et al.
Publicado: (2016)

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
por: Samson, Shiela C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a974mqs8fsmr85l511icph2cr6