Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1

Aggregation-prone proteins in neurodegenerative disease disrupt cellular protein stabilization and degradation pathways. The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by a coding polyglutamine expansion in the Ataxin-1 gene (ATXN1), which gives rise to the aggregation-...

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Detalles Bibliográficos
Autores principales: Kohiyama, Mayumi F., Lagalwar, Sarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859447/
https://www.ncbi.nlm.nih.gov/pubmed/27168726
http://dx.doi.org/10.4137/JEN.S25469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859447/
https://www.ncbi.nlm.nih.gov/pubmed/27168726
http://dx.doi.org/10.4137/JEN.S25469

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