Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding

Despite their structural and chemical commonalities, p-chloro-β-methylphenethylamine and p-methoxy-β-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional Theory (DFT) quantum chemical calculations reveal that β-methylation and para-substitu...

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Detalles Bibliográficos
Autores principales: Fierro, Angélica, Edmondson, Dale E., Celis-Barros, Cristian, Rebolledo-Fuentes, Marco, Zapata-Torres, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859490/
https://www.ncbi.nlm.nih.gov/pubmed/27152414
http://dx.doi.org/10.1371/journal.pone.0154989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859490/
https://www.ncbi.nlm.nih.gov/pubmed/27152414
http://dx.doi.org/10.1371/journal.pone.0154989

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