Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals

The rapid evolution of RNA-encoded viruses such as HIV presents a major barrier to infectious disease control using conventional pharmaceuticals and vaccines. Previously, it was proposed that defective interfering particles could be developed to indefinitely control the HIV/AIDS pandemic; in individ...

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Detalles Bibliográficos
Autores principales: Rast, Luke I., Rouzine, Igor M., Rozhnova, Ganna, Bishop, Lisa, Weinberger, Ariel D., Weinberger, Leor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859541/
https://www.ncbi.nlm.nih.gov/pubmed/27152856
http://dx.doi.org/10.1371/journal.pcbi.1004799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859541/
https://www.ncbi.nlm.nih.gov/pubmed/27152856
http://dx.doi.org/10.1371/journal.pcbi.1004799

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