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Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals
The rapid evolution of RNA-encoded viruses such as HIV presents a major barrier to infectious disease control using conventional pharmaceuticals and vaccines. Previously, it was proposed that defective interfering particles could be developed to indefinitely control the HIV/AIDS pandemic; in individ...
Autores principales: | Rast, Luke I., Rouzine, Igor M., Rozhnova, Ganna, Bishop, Lisa, Weinberger, Ariel D., Weinberger, Leor S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859541/ https://www.ncbi.nlm.nih.gov/pubmed/27152856 http://dx.doi.org/10.1371/journal.pcbi.1004799 |
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