Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-A(y) Mouse Model

Interleukin-1β (IL-1β) has been implicated as a key proinflammatory cytokine involved in the pancreatic islet inflammation of type 2 diabetes mellitus (T2DM). Excess IL-1β impairs islet function by inducing insulin resistance and β-cell apoptosis. Therefore, specifically reducing IL-1β activity prov...

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Detalles Bibliográficos
Autores principales: Zha, Jun, Chi, Xiao-wei, Yu, Xiao-lin, Liu, Xiang-meng, Liu, Dong-qun, Zhu, Jie, Ji, Hui, Liu, Rui-tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859560/
https://www.ncbi.nlm.nih.gov/pubmed/27152706
http://dx.doi.org/10.1371/journal.pone.0154298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859560/
https://www.ncbi.nlm.nih.gov/pubmed/27152706
http://dx.doi.org/10.1371/journal.pone.0154298

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