Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding

The standard 3 + 3 or “modified Fibonacci” up-and-down (MF-UD) method of dose escalation is by far the most used design in dose-finding cancer trials. However, MF-UD has always shown inferior performance when compared with its competitors regarding number of patients treated at optimal doses. A cons...

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Detalles Bibliográficos
Autores principales: Rogatko, André, Cook-Wiens, Galen, Tighiouart, Mourad, Piantadosi, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859761/
https://www.ncbi.nlm.nih.gov/pubmed/27156869
http://dx.doi.org/10.3390/e17085288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859761/
https://www.ncbi.nlm.nih.gov/pubmed/27156869
http://dx.doi.org/10.3390/e17085288

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