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Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
The standard 3 + 3 or “modified Fibonacci” up-and-down (MF-UD) method of dose escalation is by far the most used design in dose-finding cancer trials. However, MF-UD has always shown inferior performance when compared with its competitors regarding number of patients treated at optimal doses. A cons...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859761/ https://www.ncbi.nlm.nih.gov/pubmed/27156869 http://dx.doi.org/10.3390/e17085288 |