Cargando…

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect

Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life and to play important roles in tumorigenesis. Here, we show that MnSOD deficiency in skin tissues of MnSOD-heterozygous knockout (Sod2(+/−)) mice l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yong, Miriyala, Sumitra, Fang, Fang, Bakthavatchalu, Vasudevan, Noel, Teresa, Schnell, David, Wang, Chi, St Clair, William H, St Clair, Daret K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859767/ https://www.ncbi.nlm.nih.gov/pubmed/25362851 http://dx.doi.org/10.1038/onc.2014.355

Ejemplares similares

Manganese Superoxide Dismutase: Guardian of the Powerhouse
por: Holley, Aaron K., et al.
Publicado: (2011)

Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation
por: Bakthavatchalu, Vasudevan, et al.
Publicado: (2011)

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion
por: Indo, Hiroko P., et al.
Publicado: (2015)

DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling
por: Dhar, Sanjit K., et al.
Publicado: (2018)

Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis
por: Han, Yong Hwan, et al.
Publicado: (2016)

The Role of Manganese Superoxide Dismutase in Inflammation Defense
por: Li, Chang, et al.
Publicado: (2011)

The Role of Manganese Superoxide Dismutase in Skin Cancer
por: Robbins, Delira, et al.
Publicado: (2011)

The role of manganese superoxide dismutase in skin aging
por: Treiber, Nicolai, et al.
Publicado: (2012)

Insights into Manganese Superoxide Dismutase and Human Diseases
por: Liu, Mengfan, et al.
Publicado: (2022)

Metabolic Effects of Acute Thiamine Depletion Are Reversed by Rapamycin in Breast and Leukemia Cells
por: Liu, Shuqian, et al.
Publicado: (2014)

Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease
por: Wen, Jake J., et al.
Publicado: (2018)

Inverse Relationship between PSA and IL-8 in Prostate Cancer: An Insight into a NF-κB-Mediated Mechanism
por: Xu, Yong, et al.
Publicado: (2012)

miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes
por: Xu, Yong, et al.
Publicado: (2010)

Manganese and Extracellular Superoxide Dismutase Polymorphisms and Risk for Asbestosis
por: Franko, Alenka, et al.
Publicado: (2009)

Manganese Superoxide Dismutase Gene Polymorphisms in Psoriatic Arthritis
por: Yen, Jeng-Hsien, et al.
Publicado: (2004)

Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease
por: Kitada, Munehiro, et al.
Publicado: (2020)

Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis
por: Konzack, Anja, et al.
Publicado: (2015)

Association of Alanine-Valine Manganese Superoxide Dismutase Gene Polymorphism and Microheterogeneity Manganese Superoxide Dismutase Activity in Breast Cancer and Benign Breast Tissue
por: Atoum, Manar, et al.
Publicado: (2012)

Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction
por: Azadmanesh, Jahaun, et al.
Publicado: (2018)

Effect of superoxide dismutase and manganese on superoxide tolerance in Lactobacillus casei strain Shirota and analysis of multiple manganese transporters
por: SERATA, Masaki, et al.
Publicado: (2018)

Changes in Expression of Manganese Superoxide Dismutase, Copper and Zinc Superoxide Dismutase and Catalase in Brachionus calyciflorus during the Aging Process
por: Yang, Jianghua, et al.
Publicado: (2013)

Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis
por: Kamarajugadda, S, et al.
Publicado: (2013)

A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase
por: Azadmanesh, Jahaun, et al.
Publicado: (2018)

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury
por: Velez, Joyce M., et al.
Publicado: (2011)

Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force
por: Guo, Tao, et al.
Publicado: (2015)

SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy
por: Sharma, Sudha, et al.
Publicado: (2020)

Cloning, Expression and Characterization of Mitochondrial Manganese Superoxide Dismutase from the Whitefly, Bemisia tabaci
por: Gao, Xian-Long, et al.
Publicado: (2013)

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes()
por: Cyr, Anthony R., et al.
Publicado: (2013)

Mitochondrial p38β and Manganese Superoxide Dismutase Interaction Mediated by Estrogen in Cardiomyocytes
por: Liu, Han, et al.
Publicado: (2014)

Radioresistance in Prostate Cancer: Focus on the Interplay between NF-κB and SOD
por: Kumar, Sameera, et al.
Publicado: (2021)

Manganese superoxide dismutase as a diagnostic marker for malignant pleural mesothelioma
por: Kahlos, K, et al.
Publicado: (2000)

Human Manganese Superoxide Dismutase Target Sequence Polymorphism and Ovarian Cancer
por: Bag, A, et al.
Publicado: (2014)

Gene Therapy for Systemic or Organ Specific Delivery of Manganese Superoxide Dismutase
por: Greenberger, Joel S., et al.
Publicado: (2021)

Superoxide Dismutases and Superoxide Reductases
por: Sheng, Yuewei, et al.
Publicado: (2014)

Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction
por: Azadmanesh, Jahaun, et al.
Publicado: (2022)

Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses
por: Yarana, Chontida, et al.
Publicado: (2017)

Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
por: Yamashita, Nobushige, et al.
Publicado: (1999)

Absence of manganese superoxide dismutase delays p53-induced tumor formation()
por: Case, Adam J., et al.
Publicado: (2014)

Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma
por: Li, Shuai, et al.
Publicado: (2016)

Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals
por: Azadmanesh, Jahaun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_d7biakjduse17hcq2vcp97io6m