Conformational control of DNA target cleavage by CRISPR–Cas9

Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by CRISPR (clustered regularly interspaced short palindromic repeats)(1,2). Together with single-guide RNAs (sgRNA)(3), Cas9 also functions as a powerful genome engi...

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Detalles Bibliográficos
Autores principales: Sternberg, Samuel H., LaFrance, Benjamin, Kaplan, Matias, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859810/
https://www.ncbi.nlm.nih.gov/pubmed/26524520
http://dx.doi.org/10.1038/nature15544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859810/
https://www.ncbi.nlm.nih.gov/pubmed/26524520
http://dx.doi.org/10.1038/nature15544

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