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Conformational control of DNA target cleavage by CRISPR–Cas9
Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by CRISPR (clustered regularly interspaced short palindromic repeats)(1,2). Together with single-guide RNAs (sgRNA)(3), Cas9 also functions as a powerful genome engi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859810/ https://www.ncbi.nlm.nih.gov/pubmed/26524520 http://dx.doi.org/10.1038/nature15544 |