Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia

WHRN (DFNB31) mutations cause diverse hearing disorders: profound deafness (DFNB31) or variable hearing loss in Usher syndrome type II. The known role of WHRN in stereocilia elongation does not explain these different pathophysiologies. Using spontaneous and targeted Whrn mutants, we show that the m...

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Detalles Bibliográficos
Autores principales: Ebrahim, Seham, Ingham, Neil J., Lewis, Morag A., Rogers, Michael J.C., Cui, Runjia, Kachar, Bechara, Pass, Johanna C., Steel, Karen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859837/
https://www.ncbi.nlm.nih.gov/pubmed/27117407
http://dx.doi.org/10.1016/j.celrep.2016.03.081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859837/
https://www.ncbi.nlm.nih.gov/pubmed/27117407
http://dx.doi.org/10.1016/j.celrep.2016.03.081

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