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Roles for retrotransposon insertions in human disease

Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE insertions can result in single-gene disease in an individual. In humans, the non-LTR retrotr...

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Detalles Bibliográficos
Autores principales: Hancks, Dustin C., Kazazian, Haig H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859970/
https://www.ncbi.nlm.nih.gov/pubmed/27158268
http://dx.doi.org/10.1186/s13100-016-0065-9