RNAi induced hepatotoxicity results from loss of the first synthesized isoform of miR-122 in mice

Small RNAs can be used to target and eliminate expression of virtually any disease causing gene or infectious virus, resulting in their pre-clinical and clinical development for treating disease(1). To ensure success of RNAi therapeutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities...

Descripción completa

Detalles Bibliográficos
Autores principales: Valdmanis, Paul N., Gu, Shuo, Chu, Kirk, Jin, Lan, Zhang, Feijie, Munding, Elizabeth M., Zhang, Yue, Huang, Yong, Kutay, Huban, Ghoshal, Kalpana, Lisowski, Leszek, Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860119/
https://www.ncbi.nlm.nih.gov/pubmed/27064447
http://dx.doi.org/10.1038/nm.4079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860119/
https://www.ncbi.nlm.nih.gov/pubmed/27064447
http://dx.doi.org/10.1038/nm.4079

Ejemplares similares