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RNAi induced hepatotoxicity results from loss of the first synthesized isoform of miR-122 in mice

Small RNAs can be used to target and eliminate expression of virtually any disease causing gene or infectious virus, resulting in their pre-clinical and clinical development for treating disease(1). To ensure success of RNAi therapeutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities...

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Detalles Bibliográficos
Autores principales:	Valdmanis, Paul N., Gu, Shuo, Chu, Kirk, Jin, Lan, Zhang, Feijie, Munding, Elizabeth M., Zhang, Yue, Huang, Yong, Kutay, Huban, Ghoshal, Kalpana, Lisowski, Leszek, Kay, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860119/ https://www.ncbi.nlm.nih.gov/pubmed/27064447 http://dx.doi.org/10.1038/nm.4079

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