Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption

Structural basis for exploration into MDM2 and MDM2-DHFR interaction plays a vital role in analyzing the obstruction in folate metabolism, nonsynthesis of purines, and further epigenetic regulation in Homo sapiens. Therefore, it leads to suppression of normal cellular behavior and malignancy. This h...

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Detalles Bibliográficos
Autores principales: Banerjee, Arundhati, Ray, Sujay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860227/
https://www.ncbi.nlm.nih.gov/pubmed/27213086
http://dx.doi.org/10.1155/2016/9420692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860227/
https://www.ncbi.nlm.nih.gov/pubmed/27213086
http://dx.doi.org/10.1155/2016/9420692

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