Single Molecule Analysis of Laser Localized Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We have developed two strategies, both based on...

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Detalles Bibliográficos
Autores principales: Huang, Jing, Gali, Himabindu, Paramasivam, Manikandan, Muniandy, Parameswary, Gichimu, Julia, Bellani, Marina A., Seidman, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860505/
https://www.ncbi.nlm.nih.gov/pubmed/27242893
http://dx.doi.org/10.3389/fgene.2016.00084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860505/
https://www.ncbi.nlm.nih.gov/pubmed/27242893
http://dx.doi.org/10.3389/fgene.2016.00084

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