FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma

Missense mutations of fibroblast growth factor receptor 3 (FGFR3) occur in up to 80% of low-grade papillary urothelial carcinoma of the bladder (LGP-UCB) suggesting that these mutations are tumor drivers, although direct experimental evidence is lacking. Here we show that forced expression of FGFR3b...

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Detalles Bibliográficos
Autores principales: Zhou, Haiping, He, Feng, Mendelsohn, Cathy L., Tang, Moon-shong, Huang, Chuanshu, Wu, Xue-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860634/
https://www.ncbi.nlm.nih.gov/pubmed/27157475
http://dx.doi.org/10.1038/srep25596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860634/
https://www.ncbi.nlm.nih.gov/pubmed/27157475
http://dx.doi.org/10.1038/srep25596

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