Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1

While the cytoskeletal protein talin binds to the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of ta...

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Detalles Bibliográficos
Autores principales: Lim, Daina, Lu, Yuning, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860717/
https://www.ncbi.nlm.nih.gov/pubmed/26905930
http://dx.doi.org/10.1016/j.imlet.2016.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860717/
https://www.ncbi.nlm.nih.gov/pubmed/26905930
http://dx.doi.org/10.1016/j.imlet.2016.02.004

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