Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences

The Dnmt2 RNA methyltransferase catalyses the methylation of C38 in the anticodon loop of tRNA-Asp, but the molecular role of this methylation is unknown. Here, we report that mouse aspartyl-tRNA synthetase shows a four to fivefold preference for C38-methylated tRNA-Asp. Consistently, a 30% reduced...

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Detalles Bibliográficos
Autores principales: Shanmugam, Raghuvaran, Fierer, Jacob, Kaiser, Steffen, Helm, Mark, Jurkowski, Tomasz P, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860778/
https://www.ncbi.nlm.nih.gov/pubmed/27462411
http://dx.doi.org/10.1038/celldisc.2015.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860778/
https://www.ncbi.nlm.nih.gov/pubmed/27462411
http://dx.doi.org/10.1038/celldisc.2015.10

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