Structures of the APC–ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners

The tumor suppressor APC employs its conserved armadillo repeat (ARM) domain to recognize many of its binding partners, including Amer1/WTX, which is mutated in Wilms' tumor and bone overgrowth syndrome. The APC–Amer1 complex has important roles in regulating Wnt signaling and cell adhesion. Th...

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Detalles Bibliográficos
Autores principales: Zhang, Zhenyi, Akyildiz, Senem, Xiao, Yafei, Gai, Zhongchao, An, Ying, Behrens, Jürgen, Wu, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860839/
https://www.ncbi.nlm.nih.gov/pubmed/27462415
http://dx.doi.org/10.1038/celldisc.2015.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860839/
https://www.ncbi.nlm.nih.gov/pubmed/27462415
http://dx.doi.org/10.1038/celldisc.2015.16

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