EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

Transforming growth factor-β (TGF-β) induces apoptosis in many types of cancer cells and acts as a tumor suppressor. We performed a functional analysis of TGF-β signaling to identify a molecular mechanism that regulated survival in small cell lung cancer cells. Here, we found low expression of TGF-β...

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Detalles Bibliográficos
Autores principales: Murai, Fumihiko, Koinuma, Daizo, Shinozaki-Ushiku, Aya, Fukayama, Masashi, Miyaozono, Kohei, Ehata, Shogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860843/
https://www.ncbi.nlm.nih.gov/pubmed/27462425
http://dx.doi.org/10.1038/celldisc.2015.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860843/
https://www.ncbi.nlm.nih.gov/pubmed/27462425
http://dx.doi.org/10.1038/celldisc.2015.26

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