Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation

The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Described here is a second generation (18)F-labeling system based on a conformationally strained trans-cyclooctene (sTCO)—a dienophile that is approximately 2 o...

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Detalles Bibliográficos
Autores principales: Wang, Mengzhe, Svatunek, Dennis, Rohlfing, Katarina, Liu, Yu, Wang, Hui, Giglio, Ben, Yuan, Hong, Wu, Zhanghong, Li, Zibo, Fox, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860896/
https://www.ncbi.nlm.nih.gov/pubmed/27162558
http://dx.doi.org/10.7150/thno.14742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860896/
https://www.ncbi.nlm.nih.gov/pubmed/27162558
http://dx.doi.org/10.7150/thno.14742

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