A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

AIMS: Population‐based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer‐type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may result in neuronal dysfunction and contribute to...

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Detalles Bibliográficos
Autores principales: Simpson, Julie E., Ince, Paul G., Matthews, Fiona E., Shaw, Pamela J., Heath, Paul R., Brayne, Carol, Garwood, Claire, Higginbottom, Adrian, Wharton, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861215/
https://www.ncbi.nlm.nih.gov/pubmed/25443110
http://dx.doi.org/10.1111/nan.12202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861215/
https://www.ncbi.nlm.nih.gov/pubmed/25443110
http://dx.doi.org/10.1111/nan.12202

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