Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive cognitive decline leading to dementia. The amyloid precursor protein (APP) is a ubiquitous type I transmembrane (TM) protein sequentially processed to generate the β-amyloid peptide (Aβ), the major co...

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Detalles Bibliográficos
Autores principales: Decock, Marie, Stanga, Serena, Octave, Jean-Noël, Dewachter, Ilse, Smith, Steven O., Constantinescu, Stefan N., Kienlen-Campard, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861705/
https://www.ncbi.nlm.nih.gov/pubmed/27242518
http://dx.doi.org/10.3389/fnagi.2016.00107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861705/
https://www.ncbi.nlm.nih.gov/pubmed/27242518
http://dx.doi.org/10.3389/fnagi.2016.00107

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