Cargando…

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive cognitive decline leading to dementia. The amyloid precursor protein (APP) is a ubiquitous type I transmembrane (TM) protein sequentially processed to generate the β-amyloid peptide (Aβ), the major co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Decock, Marie, Stanga, Serena, Octave, Jean-Noël, Dewachter, Ilse, Smith, Steven O., Constantinescu, Stefan N., Kienlen-Campard, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861705/ https://www.ncbi.nlm.nih.gov/pubmed/27242518 http://dx.doi.org/10.3389/fnagi.2016.00107

Ejemplares similares

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing
por: Decock, Marie, et al.
Publicado: (2015)

A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology
por: Stanga, Serena, et al.
Publicado: (2018)

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
por: Contino, Sabrina, et al.
Publicado: (2017)

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease
por: Couturier, Julien, et al.
Publicado: (2016)

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
por: Doshina, Anna, et al.
Publicado: (2017)

How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor
por: Stanga, Serena, et al.
Publicado: (2020)

Characterization of the GXXXG motif in the first transmembrane segment of Japanese encephalitis virus precursor membrane (prM) protein
por: Lin, Ying-Ju, et al.
Publicado: (2010)

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides
por: Liu, Lei, et al.
Publicado: (2021)

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release
por: Opsomer, Rémi, et al.
Publicado: (2020)

Differential pairing of transmembrane domain GxxxG dimerization motifs defines two HLA-DR MHC class II conformers
por: Drake, Lisa A., et al.
Publicado: (2023)

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
por: Perrin, Florian, et al.
Publicado: (2021)

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
por: Perrin, Florian, et al.
Publicado: (2020)

β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing
por: Hu, Yi, et al.
Publicado: (2017)

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
por: Stanga, Serena, et al.
Publicado: (2017)

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates
por: Papadopoulos, Nicolas, et al.
Publicado: (2022)

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
por: Vasconcelos, Bruno, et al.
Publicado: (2016)

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo
por: Wang, Peng, et al.
Publicado: (2017)

Epigenetic Regulations of Immediate Early Genes Expression Involved in Memory Formation by the Amyloid Precursor Protein of Alzheimer Disease
por: Hendrickx, Aurélie, et al.
Publicado: (2014)

Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021)

Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty
por: Hendrickx, Aurélie, et al.
Publicado: (2013)

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
por: Stancu, Ilie-Cosmin, et al.
Publicado: (2015)

Sex-regulated gene dosage effect of PPARα on synaptic plasticity
por: Pierrot, Nathalie, et al.
Publicado: (2019)

Statistical characterization of the GxxxG glycine repeats in the flagellar biosynthesis protein FliH and its Type III secretion homologue YscL
por: Trost, Brett, et al.
Publicado: (2009)

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
por: Evrard, Caroline, et al.
Publicado: (2018)

Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability
por: Canciani, Anselmo, et al.
Publicado: (2022)

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity
por: Pierrot, Nathalie, et al.
Publicado: (2013)

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo
por: Fonte, Virginia, et al.
Publicado: (2011)

GxxxG Motif Stabilize Ion-Channel like Pores through C(α)―H···O Interaction in Aβ (1-40)
por: Rando, Carola, et al.
Publicado: (2023)

Correction: A glycine zipper motif mediates the formation of toxic beta-amyloid oligomers in vitro and in vivo
por: Fonte, Virginia, et al.
Publicado: (2014)

The Transmembrane Oligomers of Coronavirus Protein E
por: Torres, Jaume, et al.
Publicado: (2005)

Biodistribution of (99m)Tc Tricarbonyl Glycine Oligomers
por: Jang, Beom-Su, et al.
Publicado: (2012)

Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission
por: Kreis, Anna, et al.
Publicado: (2021)

Mutational Analysis of the GXXXG/A Motifs in the Human Na(+)/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function
por: Palatini, Massimo, et al.
Publicado: (2021)

The roles of aromatic residues in the glycine receptor transmembrane domain
por: Tang, Bijun, et al.
Publicado: (2018)

Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis
por: Vastl, Julian, et al.
Publicado: (2016)

Combination of Cα–H Hydrogen Bonds and van der Waals Packing Modulates the Stability of GxxxG-Mediated Dimers in Membranes
por: Anderson, Samantha M., et al.
Publicado: (2017)

Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α-Peptoids) and Derivatives
por: Culf, Adrian S., et al.
Publicado: (2010)

Mechanochemical synthesis of glycine oligomers in a virtual rotational diamond anvil cell
por: Steele, Brad A., et al.
Publicado: (2020)

MeMotif: a database of linear motifs in α-helical transmembrane proteins
por: Marsico, Annalisa, et al.
Publicado: (2010)

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
por: Xue, Li, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0djve01us52e1qvspu35ig6s9m